Retatrutide is a 39 amino acid single peptide with triple agonist activity at the glucagon receptor (GCGR), glucosedependent insulinotropic polypeptide receptor (GIPR), and glucagon-like peptide-1 receptor (GLP-1R). The backbone is conjugated to a C20 fatty diacid moiety at position 17.
Retatrutide has a Glucose-dependent insulinotropic polypeptide (GIP) peptide backbone, which then contains three non-coded amino acids. Aib2 (α-amino isobutyric acid) residues at positions 2 and 20 provide stability against Dipeptidyl Peptidase 4 (DPP4) cleavage and contribute to GIP activity. αMeL13 (α-methyl-L-leucine)at position 20 also contributes to GIP and glucagon activity.
Retatrutide can be used for the research of obesity obesity, diabetes, and fatty liver disease. It is a works in three ways: stimulating insulin release, suppressing appetite, and promoting fat breakdown.
GLP-3 is an investigational treatment for obesity that is a triple hormone receptor agonist. A gastric inhibitory polypeptide (GIP), glucagon-like peptide-1 (GLP-1) and glucagon receptor agonist.
GLP-3 may work in the treatment of obesity by targeting three different hunger regulating hormones:
What is Retatrutide (Reta-GLP-3)?
Retatrutide, also known as Reta-GLP-3, is a synthetic triple agonist peptide studied in laboratory models for its effects on body weight regulation, appetite suppression, and blood sugar control. It simultaneously targets the GLP-1, GIP, and glucagon receptors, making it a subject of interest in metabolic health, fat-burning, and diabetes-related research.
In non-human studies, Retatrutide has been explored for its ability to support fat loss, improve insulin sensitivity, and modulate energy balance. Its multi-receptor activation allows researchers to study how hormonal pathways work together in managing glucose levels, satiety signals, and body composition. The peptide is also used in lab models focused on metabolic syndrome, obesity, and cardiometabolic risk factors.
This compound is provided exclusively for in vitro scientific research and is not approved for human or veterinary use.
Retatrutide Product Specifications
| Specification | Details |
|---|---|
| Product | Retatrutide (R-GLP-3) |
| Purity | >99% (HPLC Verified) |
| Form | White Lyophilized Powder |
| Solubility | Soluble in sterile water |
| Size | 9/18 mg Vial |
| Storage Conditions | Store in a cool, dry place; refrigerate after reconstitution |
| Stability | 24 months when properly stored |
Why Choose Roid Store Retatrutide?
- Research Grade Purity: Verified purity >99% by third-party HPLC analysis.
- Secure Packaging: Engineered to maintain peptide stability and prevent degradation during shipment.
- Fast Shipping: Most orders ship within 24 hours after payment confirmation from our U.S.-based facility.
- Researcher Support: Expert customer service tailored to licensed research professionals.
Summary of Preclinical Research Findings
Blood Sugar & Insulin Regulation
Retatrutide has been studied in models focused on diabetes, fasting glucose, and insulin response. Research highlights its ability to support balanced blood sugar and improve metabolic markers through dual incretin and glucagon receptor activity.
Appetite & Weight Loss Research
Used in weight loss peptide studies, Retatrutide has been associated with reduced food intake and lower body weight in laboratory models. Researchers have investigated its influence on satiety signals, caloric intake, and digestive hormone pathways.
Fat Burning & Body Composition
Retatrutide has shown promise in fat-burning research, with studies examining changes in visceral fat, energy expenditure, and thermogenesis. It has also been explored in models tracking lean muscle retention during metabolic shifts.
Metabolic Health & Endocrine Balance
As a triple agonist, Retatrutide enables research across a broad spectrum of metabolic health topics, including lipid metabolism, hormonal interaction, and cardiometabolic markers relevant to obesity and endocrine function.
Note: All findings described above are based on non-human, preclinical laboratory research. No statements are made regarding effects in humans or animals.
Legal Disclaimer
This product is for research and educational purposes only. It is not intended for diagnostic or therapeutic use without the guidance of a qualified healthcare professional. Please refer to our terms and conditions prior to purchase.
This product comes in the form of lyophilized powder and must be reconstituted with bacteriostatic water prior to use.
Safety Information: Keep this product out of the reach of children. This material has limited research available about it and may result in adverse effects if improperly handled or consumed. This product is not a dietary supplement, but a pure substance, sold as a raw material. We attest exclusively to the quality, purity and description of the materials we provide. This product is for use and handling only by persons with the knowledge and equipment to safely handle this material. You agree to indemnify us for any adverse effects that may arise from improper handling and/or consumption of this product.
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